Advertisement
Review Article| Volume 50, ISSUE 1, P109-114, February 2023

Circulating Tumor Cells and Circulating Tumor DNA in Urologic Cancers

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Urologic Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Zhang W.
        • Xia W.
        • Lv Z.
        • et al.
        Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?.
        Cell Physiol Biochem. 2017; 41: 755-768
        • McGranahan N.
        • Swanton C.
        Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.
        Cancer Cell. 2015; 27: 15-26
        • Aghamir S.M.K.
        • Heshmat R.
        • Ebrahimi M.
        • et al.
        Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors.
        Epigenet Insights. 2020; 13 (2516865720904052)https://doi.org/10.1177/2516865720904052
        • Kidess E.
        • Jeffrey S.S.
        Circulating tumor cells versus tumor-derived cell-free DNA: rivals or partners in cancer care in the era of single-cell analysis?.
        Genome Med. 2013; 5: 70
        • Ashworth T.R.
        A Case of Cancer in Which Cells Similar to Those in the Tumours Were Seen in the Blood after Death.
        Med J Aust. 1869; 14: 146-147
        • Mandel P.
        • Metais P.
        Nuclear Acids In Human Blood Plasma.
        C R Seances Soc Biol Fil. 1948; 142 (Les acides nucleiques du plasma sanguin chez l'homme): 241-243
        • Anker P.
        • Stroun M.
        • Maurice P.A.
        Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system.
        Cancer Res. 1975; 35: 2375-2382
        • Jahr S.
        • Hentze H.
        • Englisch S.
        • et al.
        DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.
        Cancer Res. 2001; 61: 1659-1665
        • Bronkhorst A.J.
        • Wentzel J.F.
        • Aucamp J.
        • et al.
        Characterization of the cell-free DNA released by cultured cancer cells.
        Biochim Biophys Acta. 2016; 1863: 157-165
        • Thiery J.P.
        • Lim C.T.
        Tumor dissemination: an EMT affair.
        Cancer Cell. 2013; 23: 272-273
        • McDonald D.M.
        • Baluk P.
        Significance of blood vessel leakiness in cancer.
        Cancer Res. 2002; 62: 5381-5385
        • Cristofanilli M.
        • Budd G.T.
        • Ellis M.J.
        • et al.
        Circulating tumor cells, disease progression, and survival in metastatic breast cancer.
        N Engl J Med. 2004; 351: 781-791
        • Stroun M.
        • Lyautey J.
        • Lederrey C.
        • et al.
        About the possible origin and mechanism of circulating DNA apoptosis and active DNA release.
        Clin Chim Acta. 2001; 313: 139-142
        • Joosse S.A.
        • Gorges T.M.
        • Pantel K.
        Biology, detection, and clinical implications of circulating tumor cells.
        EMBO Mol Med. 2015; 7: 1-11
        • Scholer L.V.
        • Reinert T.
        • Orntoft M.W.
        • et al.
        Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer.
        Clin Cancer Res. 2017; 23: 5437-5445
        • Diehl F.
        • Schmidt K.
        • Choti M.A.
        • et al.
        Circulating mutant DNA to assess tumor dynamics.
        Nat Med. 2008; 14: 985-990
        • Aceto N.
        • Bardia A.
        • Miyamoto D.T.
        • et al.
        Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
        Cell. 2014; 158: 1110-1122
        • Alix-Panabieres C.
        • Pantel K.
        Technologies for detection of circulating tumor cells: facts and vision.
        Lab Chip. 2014; 14: 57-62
        • Allard W.J.
        • Matera J.
        • Miller M.C.
        • et al.
        Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases.
        Clin Cancer Res. 2004; 10: 6897-6904
        • Saucedo-Zeni N.
        • Mewes S.
        • Niestroj R.
        • et al.
        A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire.
        Int J Oncol. 2012; 41: 1241-1250
        • Ozkumur E.
        • Shah A.M.
        • Ciciliano J.C.
        • et al.
        Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.
        Sci Transl Med. 2013; 5: 179ra47
        • Xu L.
        • Mao X.
        • Imrali A.
        • et al.
        Optimization and evaluation of a novel size based circulating tumor cell isolation system.
        PLoS One. 2015; 10: e0138032
        • Siravegna G.
        • Marsoni S.
        • Siena S.
        • et al.
        Integrating liquid biopsies into the management of cancer.
        Nat Rev Clin Oncol. 2017; 14: 531-548
        • Postel M.
        • Roosen A.
        • Laurent-Puig P.
        • et al.
        Droplet-based digital PCR and next generation sequencing for monitoring circulating tumor DNA: a cancer diagnostic perspective.
        Expert Rev Mol Diagn. 2018; 18: 7-17
        • Shen S.Y.
        • Singhania R.
        • Fehringer G.
        • et al.
        Sensitive tumour detection and classification using plasma cell-free DNA methylomes.
        Nat Nov. 2018; 563: 579-583
        • Siegel R.L.
        • Miller K.D.
        • Fuchs H.E.
        • et al.
        Cancer statistics.
        CA Cancer J Clin. 2022; 72: 7-33
        • Hennigan S.T.
        • Trostel S.Y.
        • Terrigino N.T.
        • et al.
        Low Abundance of Circulating Tumor DNA in Localized Prostate Cancer.
        JCO Precis Oncol. 2019; https://doi.org/10.1200/PO.19.00176
        • de Bono J.S.
        • Scher H.I.
        • Montgomery R.B.
        • et al.
        Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer.
        Clin Cancer Res. 2008; 14: 6302-6309
        • Nagaya N.
        • Nagata M.
        • Lu Y.
        • et al.
        Prostate-specific membrane antigen in circulating tumor cells is a new poor prognostic marker for castration-resistant prostate cancer.
        PLoS One. 2020; 15: e0226219
        • Miyamoto D.T.
        • Lee R.J.
        • Stott S.L.
        • et al.
        Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.
        Cancer Discovery. 2012; 2: 995-1003
        • Armstrong A.J.
        • Halabi S.
        • Luo J.
        • et al.
        Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study.
        J Clin Oncol. 2019; 37: 1120-1129
        • Scher H.I.
        • Heller G.
        • Molina A.
        • et al.
        Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer.
        J Clin Oncol. 2015; 33: 1348-1355
        • Heller G.
        • McCormack R.
        • Kheoh T.
        • et al.
        Circulating Tumor Cell Number as a Response Measure of Prolonged Survival for Metastatic Castration-Resistant Prostate Cancer: A Comparison With Prostate-Specific Antigen Across Five Randomized Phase III Clinical Trials.
        J Clin Oncol. 20 2018; 36: 572-580
        • Wyatt A.W.
        • Azad A.A.
        • Volik S.V.
        • et al.
        Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer.
        JAMA Oncol. 2016; 2: 1598-1606
        • Goodall J.
        • Mateo J.
        • Yuan W.
        • et al.
        Circulating cell-free DNA to guide prostate cancer treatment with PARP inhibition.
        Cancer Discovery. 2017; 7: 1006-1017
        • Morris M.J.
        • Molina A.
        • Small E.J.
        • et al.
        Radiographic progression-free survival as a response biomarker in metastatic castration-resistant prostate cancer: COU-AA-302 results.
        J Clin Oncol. 2015; 33: 1356-1363
        • Mateo J.
        • Porta N.
        • Bianchini D.
        • et al.
        Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial.
        Lancet Oncol. 2020; 21: 162-174
        • Lorente D.
        • Olmos D.
        • Mateo J.
        • et al.
        Decline in Circulating Tumor Cell Count and Treatment Outcome in Advanced Prostate Cancer.
        Eur Urol. 2016; 70: 985-992
        • Herberts C.
        • Annala M.
        • Sipola J.
        • et al.
        Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.
        Nature. 2022; 608: 199-208
        • Jordan B.
        • Meeks J.J.
        T1 bladder cancer: current considerations for diagnosis and management.
        Nat Rev Urol. 2019; 16: 23-34
        • Chang S.S.
        • Bochner B.H.
        • Chou R.
        • et al.
        Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline.
        J Urol Sep. 2017; 198: 552-559
        • Busetto G.M.
        • Ferro M.
        • Del Giudice F.
        • et al.
        The Prognostic Role of Circulating Tumor Cells (CTC) in High-risk Non-muscle-invasive Bladder Cancer.
        Clin Genitourin Cancer. 2017; 15: e661-e666
        • Gradilone A.
        • Petracca A.
        • Nicolazzo C.
        • et al.
        Prognostic significance of survivin-expressing circulating tumour cells in T1G3 bladder cancer.
        BJU Int. 2010; 106: 710-715
        • Rink M.
        • Chun F.K.
        • Minner S.
        • et al.
        Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer.
        BJU Int. 2011; 107: 1668-1675
        • Flaig T.W.
        • Wilson S.
        • van Bokhoven A.
        • et al.
        Detection of circulating tumor cells in metastatic and clinically localized urothelial carcinoma.
        Urology. 2011; 78: 863-867
        • Naoe M.
        • Ogawa Y.
        • Morita J.
        • et al.
        Detection of circulating urothelial cancer cells in the blood using the CellSearch System.
        Cancer. 2007; 109: 1439-1445
        • Birkenkamp-Demtroder K.
        • Nordentoft I.
        • Christensen E.
        • et al.
        Genomic Alterations in Liquid Biopsies from Patients with Bladder Cancer.
        Eur Urol. 2016; 70: 75-82
        • Christensen E.
        • Birkenkamp-Demtroder K.
        • Nordentoft I.
        • et al.
        Liquid Biopsy Analysis of FGFR3 and PIK3CA Hotspot Mutations for Disease Surveillance in Bladder Cancer.
        Eur Urol. 2017; 71: 961-969
        • Christensen E.
        • Birkenkamp-Demtroder K.
        • Sethi H.
        • et al.
        Early detection of metastatic relapse and monitoring of therapeutic efficacy by ultra-deep sequencing of plasma cell-free DNA in patients with urothelial bladder carcinoma.
        J Clin Oncol. 2019; 37: 1547-1557
        • Agarwal N.
        • Pal S.K.
        • Hahn A.W.
        • et al.
        Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA.
        Cancer. 2018; 124: 2115-2124
        • Motzer R.J.
        • Jonasch E.
        • Agarwal N.
        • et al.
        Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
        J Natl Compr Canc Netw. 2022; 20: 71-90
        • Janzen N.K.
        • Kim H.L.
        • Figlin R.A.
        • et al.
        Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease.
        Urol Clin North Am. 2003; 30: 843-852
        • Bluemke K.
        • Bilkenroth U.
        • Meye A.
        • et al.
        Detection of circulating tumor cells in peripheral blood of patients with renal cell carcinoma correlates with prognosis.
        Cancer Epidemiol Biomarkers Prev. 2009; 18: 2190-2194
        • Nel I.
        • Gauler T.C.
        • Bublitz K.
        • et al.
        Circulating Tumor Cell Composition in Renal Cell Carcinoma.
        PLoS One. 2016; 11: e0153018
        • Wan J.
        • Zhu L.
        • Jiang Z.
        • et al.
        Monitoring of plasma cell-free DNA in predicting postoperative recurrence of clear cell renal cell carcinoma.
        Urol Int. 2013; 91: 273-278
        • Skrypkina I.
        • Tsyba L.
        • Onyshchenko K.
        • et al.
        Concentration and Methylation of Cell-Free DNA from Blood Plasma as Diagnostic Markers of Renal Cancer.
        Dis Markers. 2016; 2016: 3693096
        • Yamamoto Y.
        • Uemura M.
        • Fujita M.
        • et al.
        Clinical significance of the mutational landscape and fragmentation of circulating tumor DNA in renal cell carcinoma.
        Cancer Sci. 2019; 110: 617-628
        • Zill O.A.
        • Banks K.C.
        • Fairclough S.R.
        • et al.
        The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients.
        Clin Cancer Res. 2018; 24: 3528-3538
        • Hahn A.W.
        • Gill D.M.
        • Maughan B.
        • et al.
        Correlation of genomic alterations assessed by next-generation sequencing (NGS) of tumor tissue DNA and circulating tumor DNA (ctDNA) in metastatic renal cell carcinoma (mRCC): potential clinical implications.
        Oncotarget. 2017; 8: 33614-33620
        • Pal S.K.
        • Sonpavde G.
        • Agarwal N.
        • et al.
        Evolution of Circulating Tumor DNA Profile from First-line to Subsequent Therapy in Metastatic Renal Cell Carcinoma.
        Eur Urol. 2017; 72: 557-564